Products
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L-Lysine-S-Carboxy Methyl-L-Cysteine
Posted: 07 Dec 2009 Product name: L-Lysine-S-Carboxy Methyl-L-Cysteine Synonyme: L-Carbocysteine-Lysine, SCMC-LysCAS#: 49673-81-6 |
Product name: L-Lysine-S-Carboxy Methyl-L-Cysteine Synonyme: L-Carbocysteine-Lysine, SCMC-LysCAS#: 49673-81-6Molecular Formula: C6H14N2O2.C5H9NO4SSpecification: 98%Function:Carbocysteine lysine salt monohydrate (SCMC-Lys) is a well-known mucoactive drug whose therapeutic efficacy is commonly related to the ability of SCMC-Lys to replace fucomucins by sialomucins. The aim of this study was to determine if SCMC-Lys couldexert an anti-oxidant action by scavenging reactive oxygen intermediates (ROIs). Our results show that SCMC-Lys proved effective as a selective scavenger of hypochlorous acid (HOCl) and hydroxyl radical (OH.), this effect being related to the reactivity of the SCMC tioether group. The scavenger activity of SCMC-Lys was observed in free cellular system as well as in activated human polymorphonuclear neutrophils (PMNs). SCMC-Lys scavenger activity on HOCl was paralleled by a powerful protection from HOCl-mediated inactivation ofalpha1-antitripsin (alpha1-AT) inhibitor, the main serum protease inhibitor. Production of interleukin-(IL-)8, a major mediator of PMN recruitment in inflammatory diseases, is known to be mediated by intracellular OH.SCMC-Lys significantly reduced IL-8 production on stimulated human peripheral blood mononuclear cells (PBMCs) in the same range of concentrations affecting OH. activity. It is concluded that SCMC-Lys could exert, in addition to its mucoactive capacity, an anti-oxidant action, thus contributing to the therapeutic efficacy of SCMC-Lys. |
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| Price Range: |
12 -
25
EUR |
| FOB/Port: |
Ningbo |
| Payment Terms: |
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| Minimum Quantity: |
100
Kilogram |
| Model: |
5 |
| Sample Available: |
Yes ( for
100
EUR plus shipping
500 )
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| Member since: 07 Dec 2009 Ningbo Honor Chemtech Co., Ltd. founded in Feb. 2007, is a hi-tech share-holding corporation, located in Ningbo, which is a seaport city, in the shore of Donghai Sea. Manufacturer from Ningbo, China |
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